1

Welcome and role call

BGO, all

2

Allergy model

BGO

• Items raised during last ECE call

• Why are hypersensitivity conditions/dispositions clinical findings rather than disorders?

  • Disorders have a clinical/pathologic manifestation and are defined by pathological processes or structures whereas dispositions are potential disorders that do not have manifestations until realized as a pathological process

• Extending the range of has realization to include pathological process

  • To be used only for dispositions

  • Impact on drug model which also has a disposition relationship needs to be examined

  • Stefan Shultz has supported this approach

• BGO will write up editorial guidelines for new hypersensitivity/allergy model

3

Pregnancy complications

BGO

• General agreement on proposed models. More testing required.

• Create new concepts for childbirth (finding) and labor (finding)

3

Device complications

BGO

• General agreement on proposed models. More testing required.

• Discussion on infected devices tabled for next call

4

Manifestations of disorders

BGO

• Does a manifestation of a disorder represent a single condition or a combined life phase of the manifestation with the underlying disorder?

• Is there a causal relationship between the manifestation and the underlying disorder?

• Model as pattern 1 (simple co-occurrence), manifestation co-occurrent with underlying disorder for now

• May add a due to relationship as well in future pending further testing

5

Cerebrovascular accident due to arterial thrombosis/embolus

BGO

• Question as how to model occlusive nature of thrombus as cause of CVA

• Proposed model

  • Create occlusive arterial thrombosis defined with an associated morphology of occlusive thrombus

  • Model as isA CVA due to occlusive arterial thrombosis (disorder)

  • Test model in SCA - done

  • BGO to create editorial guidelines for above model

6

AOB, adjourn

ALL

• Next meeting June 5, 2017 2000 UTC