Disease of [body structure] caused by varicella zoster virus (disorder) - v1.0
Status | For review |
|---|---|
Version | 0.5 |
Descriptions:
Term | description type | Language/acceptability | Language/acceptability | Case significance |
|---|---|---|---|---|
[courses] herpes zoster [morphology] of [body structure] caused by varicella zoster virus (disorder) | FSN | us:P | gb:P | ci |
[courses] herpes zoster [morphology] of [body structure] caused by varicella zoster virus | SYN | us:P | gb:P | ci |
There are several concepts in SNOMED CT of the type Herpes zoster X (disorder) modeled with after
38907003 |Varicella (disorder)|implying these are complications of herpes zoster but in reality may just be complications of primary varicella zoster infection.
Concept model:
Attribute cardinality | Attribute | Value | role group number | Role group cardinality |
|---|---|---|---|---|
1..1 | {"timestamp":1792060875086,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} |
{"timestamp":1792060875092,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | N/A |
0..1 | {"timestamp":1792060875130,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1792060875125,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | 0..1 |
1..1 | {"timestamp":1792060875117,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1792060875121,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | 1..1 |
0..1 | {"timestamp":1792060875139,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1792060875171,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 1 | 1..1 |
0..1 | 1 | |||
1..1 | 1 | |||
1..1 | 1 |
Definition status:
Applies to
Rules for generating descriptions:
Comments
Bruce Goldberg Should causative agent be << 19551004|Human herpesvirus 3 (organism)| with cardinality of 1..1 ? Should the associated morphology be << 409774005|Inflammatory morphology (morphologic abnormality)|?
In all cases, the pathologic substrate for zoster is varying degrees of ganglionic hemorrhage and inflammation. In 1900, Head and Campbell32 published their classic and detailed autopsy studies on 21 patients with shingles; their monograph was recently reviewed by Oaklander,25 who noted the near impossibility of duplicating such extensive CNS and PNS dissections today. More recently, Nagashima and coworkers33 and Ghatak and Zimmerman34 also reported hemorrhage, necrosis, and inflammation within affected spinal ganglia of patients with zoster. Collectively, these reports and our own experience suggest considerable variability among patients and among multiple ganglia from a single patient in the degree of changes present in individual ganglia; this variability underscores the need for extensive dissection of the ganglia at autopsy. The histologic features may include mononuclear and lymphocytic inflammation, neuronal degeneration, neuronal phagocytosis by satellite cells, and empty neuronal cell beds, with eventual fibrous scarring of the ganglia 4,25 (Figure 7). Vasculitis in the adjacent nerve results in the loss of myelin and axons,4 which can result in limb paresis.35 Interestingly, in contrast to latent VZV during which the virus is found only in the neurons of ganglia,20,21 zoster is characterized by viral inclusions and viral particles detectable by light and electron microscopy, respectively, in neurons, satellite cells, and fibroblast-like cells of ganglia.33,34
B. K. Kleinschmidt-DeMasters and Donald H. Gilden (2001) Varicella-Zoster Virus Infections of the Nervous System. Archives of Pathology & Laboratory Medicine: June 2001, Vol. 125, No. 6, pp. 770-780.
Hi Bruce Goldberg Does it mean that inflammation is no longer the default morphology? If it is inflammation, it would be called herpes zoster. If morphology is different from inflammation, it would be termed by [morphology] caused by varicella zoster virus.
Hi Yongsheng Gao. I forgot about this article but as it states inflammation is always present with other histologic features perhaps less consistent, I can go back to an associated morphology of inflammation. This also raises questions about the finding site. Should there be 2 finding sites, one for sensory ganglion and one for << 123037004 |Body structure (body structure)|. Or maybe nerve structure? Disorders such as Zoster retinitis are tricky because in SNOMED, retina has no association with the nervous system although technically it is part of the CNS.
Bruce