Adverse [finding site] reaction to [agent](disorder) - v2.0

Adverse [finding site] reaction to [agent] (disorder)

FSN

us:P

gb:P

ci

Adverse [finding site] reaction to [agent]

SYN

us:P

gb:P

ci

1..1

N/A

1..1

1..1

0..1

Substance base

yes

Adverse reaction concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 292392003 |Fluphenazine adverse reaction (disorder)|

Expected classification:

• Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.

Substance modification

no, unless documented as exception

Adverse reaction concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the adverse reaction profile is significantly different from the substance base.

Exception examples:

• Chemical element with multiple modifications (e.g. 422232005 |Calcium lactate gluconate (substance)|)

• Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)

• Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)

• Salt forms (e.g. 412432007 |Metoprolol succinate (substance)|, 72770009 |Metoprolol tartrate (substance)|)

Example:

• 292389002 |Fluphenazine decanoate adverse reaction (disorder)|

• 292390006 |Fluphenazine enanthate adverse reaction (disorder)|

Expected classification:

• Classification results are expected to reflect that the concept modeled with the modified substance is a descendant of the concept modeled with the base substance (if such a concept exists (e.g. 292389002 |Fluphenazine decanoate adverse reaction (disorder)| has inferred parent 292392003 |Fluphenazine adverse reaction (disorder)|).

Multiple substance

yes

Adverse reaction concepts representing multiple substances should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base.

Example:

• 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)|

• 292987009 |Piperacillin and tazobactam adverse reaction (disorder)|

• 292989007 |Ticarcillin and clavulanic acid adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.

Disposition grouper

yes

Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 293432006 |3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction (disorder)|

• 870376001 |Adverse reaction to dopamine receptor agonist (disorder)|

Expected classification results:

• Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy (e.g. 292113001 |Lansoprazole adverse reaction (disorder)| has inferred parent 292111004 |Proton pump inhibitor adverse reaction (disorder)|).

Role grouper

yes

Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

Example:

• 430136001 |Adverse reaction caused by antiparkinsonism drug (disorder)|

• 292040004 |Analgesic adverse reaction (disorder)|

Expected classification results (Agreed 21-Jan-2020):

• Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy (e.g. 292113001 |Lansoprazole adverse reaction (disorder)| has inferred parent 292111004 |Proton pump inhibitor adverse reaction (disorder)|).

•  

• Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.

Structure grouper

yes

Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|

• 419885006 |Beta lactam adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Descendant of 373873005 |Pharmaceutical / biologic product (product)|

no, unless documented as exception

Exceptions: None identified