2021-11-29 - Cancer Synoptic Reporting Project Group Meeting

1

Status of initial sub

@Scott Campbell

• Confirm date of 2021-10-31 availability

2

Intactness/quality of specimen concepts

@Scott Campbell

1. Discuss representation of "intactness" and specimen quality (colon, ovary, thyroid)
   
   
   

2. Confirm Business Meeting Conclusion

Approach agreed upon.  Create new concept |Anatomic integrity (property)|.  When used with |Inheres in| = some (specimen), then the discussion is about the anatomic integrity of the specimen which is appropriate for CSRWG observations.

When used with |Inheres in| = some (body structure), the discussion is about the anatomic integrity of the body structure as is the case discussed pertaining to in vivo observations.

3

IHC

@Scott Campbell

Discuss model, adjust as necessary, inclusion of related gene?

See example in authoring platform

How to represent location of protein expression? (cytoplasmic, nuclear...)

1. Generic model for presence of protein by IHC discussed and tentatively agreed upon.  COMPONENT = <<SUBSTANCE
   
   No relationship to gene necessary here.
   
   
   

2. @Scott Campbellto generate model for review with examples.  How/if to represent nuclear, membranous, cytoplasmic protein

3. @Scott Campbell to expand on generic molecular and cytogenetic model

4

Primary/metastasis

@Scott Campbell

Discuss modeling changes regarding primary vs. metastatic growth (from/to)