LOINC Property - Likelihood and associated LOINC terms

Hi all,

We are looking for feedback related to this LOINC part and associated LOINC terms.

RELMA defines this property as following: “Risk is the probability (chance) of a certain event happening, such as developing a particular disease or inheriting a specific mutation. Risk can be represented as a fraction or a percent. For example, a 1 in 1,000 chance can be represented as 1/1,000 or 0.1%.”

Example LOINC terms that are using this property:

LOINC_NUM	LONG_COMMON_NAME	COMPONENT	PROPERTY	TIME_ASPCT	SYSTEM	SCALE_TYP	METHOD_TYP
43995-0	Trisomy 21 risk [Likelihood] in Fetus	Trisomy 21 risk	Likelihood	Pt	^Fetus	Qn
49090-4	Fetal Trisomy 21 risk [Likelihood] Based on maternal age	Trisomy 21 risk	Likelihood	Pt	^Fetus	Qn	Based on maternal age
73970-6	Fetal Trisomy 21 risk [Likelihood] based on Plasma cell-free DNA by Dosage of chromosome-specific cfDNA	Trisomy 21 risk	Likelihood	Pt	Plas.cfDNA	Qn	Dosage of chromosome specific cf DNA
75561-1	Fetal Trisomy 21 risk [Likelihood] based on Plasma cell-free+WBC DNA by Dosage of chromosome-specific cfDNA	Trisomy 21 risk	Likelihood	Pt	WBC.DNA+Plas.cfDNA	Qn	Dosage of chromosome specific cf DNA
75563-7	Fetal Trisomy 21 risk [Likelihood] based on Plasma cell-free+WBC DNA by Dosage of chromosome-specific cfDNA Narrative	Trisomy 21 risk	Likelihood	Pt	WBC.DNA+Plas.cfDNA	Nar	Dosage of chromosome specific cf DNA

For creating post coordinated expression for the examples noted above, our proposal is to:

Create new component concept as following:
7894007 | Karyotype morphology (morphologic abnormality)
78989007 | Trisomy (morphologic abnormality)
NEW | Trisomy 21 (morphologic abnormality)
Create a new property as following
New | Likelihood (property) (qualifier value)

Other attributes (including method) will be mapped as specified in the LOINC terms.

Best Regards,

Farzaneh

CC: @Suzanne Santamaria