Botulism - revised template - for review
Descriptions:
Term | description type | Language/acceptability | Language/acceptability | Case significance |
|---|---|---|---|---|
[X] Botulism (disorder) | FSN | us:P | gb:P | ci |
[X] Botulism | SYN | us:P | smgb:P | ci |
Concept model:
Attribute cardinality | Attribute | Value | role group number | Role group cardinality |
|---|---|---|---|---|
1..1 | {"timestamp":1794272886474,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1794272886463,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | N/A |
1..1 | {"timestamp":1794272886486,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1794272886480,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | N/A |
1..1 | {"timestamp":1794272886507,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1794272886500,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | N/A |
0..1 | {"timestamp":1794272886510,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | {"timestamp":1794272886494,"msg":"A unknown Exception Occurred","errorMsg":"The provided AtlassianHostUser did not specify a user to act as.","code":"500"} | 0 | N/A |
1..1 | 1 | 1..1 | ||
1..1 | 1 | |||
0..1 | 2 | 1..1
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1..1 | 2 | |||
0..1 | 3 | 0..1 | ||
0..1 | 3 | |||
0..1 | 3 | |||
1..1 | 3 | |||
1..1 | 3 |
Definition status:
Applies to
Template Language
Link to the misaligned concept report
Due to Disease - https://docs.google.com/spreadsheets/d/1I_Bv8OZAFwikvpGorX03XqKplzbCdsrxIi4UG6u85AQ/edit#gid=0
Due to Disease or Procedure - https://docs.google.com/spreadsheets/d/10P1850T9c8PtmKL4EfiGEPZDSgbf6WFdDFckl1Xixzw/edit#gid=0
Rules for generating descriptions:
Comments
The best model I could come up with for the top level "botulism" concept based on information from UpToDate is below. There is no morphology for this disorder. It is due to inhibition of acetlycholine release that occurs after the toxin binds to presynaptic receptors and is internalized. There is undoubtedly a pathological process going on but I am having a hard time identifying what it is. I am going to delete my task and start over if you agree with the model. I will modify the template after my testing is completed to everyone's satisfaction.
I can now see (based on the UpToDate) info where Neuroparalytic syndrome caused by Clostridium botulinum toxin is distinct from other possible manifestations of botulism but I wonder if it is necessary to call this out as paralysis is an integral part of the syndrome?
Thanks Niki. This brings up a question:
I am wondering what is the difference between 840421000 |Disorder of neuromuscular junction caused by botulinum toxin (disorder)|, 863964005 |Neuroparalytic syndrome caused by Clostridium botulinum toxin (disorder)| and just plain old 414531002 |Intoxication with Clostridium botulinum toxin (disorder)|? Why not just call this botulism which I think is universally understandable? I will update the template to reflect the paralysis and neuromuscular junction disorder. I have to determine an appropriate morphology for the finding site of neuromuscular junction as I am not sure damage is correct.
Hello Bruce Goldberg agree Damage may not be the best morphology I did try to find something better but you are right there probably is no morphology. Parent would be 17940001 |Toxic neuromuscular junction disorder (disorder)|
Would the causative agent and finding site be role-grouped in the screenshot examples above?
Re your question: I wonder if it is necessary to call this out as paralysis is an integral part of the syndrome?
For 'Neuroparalytic syndrome caused by Clostridium botulinum toxin' my thinking is that, similar to Orphanet modelling, where if a manifestation is named in the FSN and is always present then it is modelled in SNOMED.
Hello Penni Hernandez (Unlicensed) Bruce Goldberg Jim Case
As discussed at the QI meeting on Wed 11 March I have a CRS request in a task in progress about the botulism synonyms (Matt Cordell) and I have been working on this task CRSJUL20-582 with Penni as first reviewer and I have now added Bruce and Jim as requested.
Yesterday (prior to viewing this template) I researched the area and based on my findings have created a new concept 863964005 |Neuroparalytic syndrome caused by Clostridium botulinum toxin (disorder)| with the Due to relationship of Intoxication with Clostridium botulinum toxin (disorder). For 409562009 |Inhalational botulism (disorder)|I have added an After relationship to Inhalation of substance (event). The 398523009 |Foodborne botulism (disorder)| and subtypes have been modelled with a Due to relationship of Consumption of contaminated food (event) and isa Poisoning (disorder) in addition to the stated parent Neuromuscular junction disorder (disorder).
There are definite similarities to the template model Bruce has developed here and based on research evidence (colonisation) 398530003 |Wound botulism (disorder)| and 409563004 |Intestinal botulism (disorder)| have been modelled with Pathological process Infectious process (qualifier value).
With agreement from Jim 38719000 |Toxicoinfectious botulism (disorder)| has been inactivated in a separate task just promoted as non-human content.
Ref: https://www.uptodate.com/contents/botulism?search=botulism%20immune%20globulin&source=search_result&selectedTitle=2~7&usage_type=default&display_rank=1