Squamous cell carcinoma
Please note the following are subject to change until the time of release.
Summary of changes made to squamous cell carcinoma content:
Content reviewed <<1162767002 |Squamous cell carcinoma (morphologic abnormality)| and content using <<1162767002 |Squamous cell carcinoma (morphologic abnormality)| in definitions.
Descriptions updated to reflect editorial guidance and current clinical nomenclature.
Use of HPV-independent and HPV-associated
Squamous cell carcinoma treatment is highly contingent on the presence/absense of HPV in the disease process. It is assessed using p16 IHC and the pattern of staining observed.
HPV-independent and HPV-associated SCC are reported differently and use different synoptic protocols for purposes of pathology reporting
As such, HPV-independent and HPV-associated SCC morphologies subtypes were created and classified as subtypes of the HPV-independent/associated SCC morphology concept.
Disorders referenced as Buschke-Löwenstein such as: 402911002 |Penile verrucous carcinoma of Buschke-Löwenstein (disorder)| have been inactivated as outdated and possibly replaced by concepts defined by Giant condyloma acuminatus or malignant verrucous carcinoma. Current medical understanding and nomenclature separates these two morphologies. It is unclear if historical diagnoses represented the condylomatous condition or the malignant carcinoma condition.
List of concepts added and inactivated:
28 new concepts added:
Id | FSN |
1409180004 | Giant condyloma acuminatum of anus (disorder) |
1409175008 | Giant condyloma acuminatum of penis (disorder) |
1409176009 | Giant condyloma acuminatum of vulva (disorder) |
1409179002 | Malignant verrucous carcinoma of anus (disorder) |
1409174007 | Malignant verrucous carcinoma of penis (disorder) |
1402256009 | Malignant nonkeratinizing squamous cell carcinoma of lung (disorder) |
1409177000 | Malignant verrucous carcinoma of vulva (disorder) |
1402257000 | Primary malignant nonkeratinizing squamous cell carcinoma of lung (disorder) |
1409099005 | Primary malignant squamous cell carcinoma of cervix (disorder) |
1409098002 | Primary malignant serous carcinoma of body of uterus (disorder) |
1409170003 | Condyloma acuminatum (morphologic abnormality) |
1402265002 | Malignant human papillomavirus associated adenosquamous carcinoma (morphologic abnormality) |
1402269008 | Malignant human papillomavirus associated basaloid squamous cell carcinoma (morphologic abnormality) |
1402266001 | Malignant human papillomavirus associated ciliated adenosquamous carcinoma (morphologic abnormality) |
1402264003 | Malignant human papillomavirus associated papillary squamous cell carcinoma (morphologic abnormality) |
1402267005 | Malignant human papillomavirus associated lymphoepithelial carcinoma (morphologic abnormality) |
1402268000 | Malignant human papillomavirus associated spindle cell squamous cell carcinoma (morphologic abnormality) |
1402273006 | Malignant human papillomavirus independent ciliated adenosquamous carcinoma (morphologic abnormality) |
1402274000 | Malignant human papillomavirus independent adenosquamous carcinoma (morphologic abnormality) |
1402270009 | Malignant human papillomavirus independent basaloid squamous cell carcinoma (morphologic abnormality) |
1402275004 | Malignant human papillomavirus independent papillary squamous cell carcinoma (morphologic abnormality) |
1402263009 | Malignant keratinizing human papillomavirus associated squamous cell carcinoma (morphologic abnormality) |
1402279005 | Malignant human papillomavirus independent lymphoepithelial carcinoma (morphologic abnormality) |
1402271008 | Malignant human papillomavirus independent spindle cell squamous cell carcinoma (morphologic abnormality) |
1402277007 | Malignant nonkeratinizing human papillomavirus independent squamous cell carcinoma (morphologic abnormality) |
1402276003 | Malignant keratinizing human papillomavirus independent squamous cell carcinoma (morphologic abnormality) |
1402262004 | Malignant nonkeratinizing human papillomavirus associated squamous cell carcinoma (morphologic abnormality) |
1366051002 | Malignant nonkeratinizing squamous cell carcinoma (morphologic abnormality) |
25 concepts inactivated:
Id | FSN | Reason | Assoc Type | Assoc Value |
402910001 | Anogenital verrucous carcinoma of Buschke-Löwenstein (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409179002 |Malignant verrucous carcinoma of anus (disorder)| |
402910001 | Anogenital verrucous carcinoma of Buschke-Löwenstein (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409180004 |Giant condyloma acuminatum of anus (disorder)| |
402911002 | Penile verrucous carcinoma of Buschke-Löwenstein (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409174007 |Malignant verrucous carcinoma of penis (disorder)| |
402911002 | Penile verrucous carcinoma of Buschke-Löwenstein (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409175008 |Giant condyloma acuminatum of penis (disorder)| |
1197266009 | Primary papillary carcinoma of body of uterus (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 371971003 |Primary malignant neoplasm of body of uterus (disorder)| |
1197266009 | Primary papillary carcinoma of body of uterus (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409098002 |Primary malignant serous carcinoma of body of uterus (disorder)| |
1197268005 | Primary papillary carcinoma of cervix uteri (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 184781000119102 |Primary adenocarcinoma of cervix uteri (disorder)| |
1197268005 | Primary papillary carcinoma of cervix uteri (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409099005 |Primary malignant squamous cell carcinoma of cervix (disorder)| |
707408006 | Primary small cell non-keratinizing squamous cell carcinoma of lung (disorder) | OUTDATED | REPLACED BY | 1402257000 |Primary malignant nonkeratinizing squamous cell carcinoma of lung (disorder)| |
1259446001 | Primary undifferentiated nonkeratinizing squamous cell carcinoma of nasopharynx (disorder) | OUTDATED | REPLACED BY | 1259470002 |Primary malignant nonkeratinizing squamous cell carcinoma of nasopharynx (disorder)| |
1293093002 | Pseudovascular squamous cell carcinoma (disorder) | OUTDATED | REPLACED BY | 403901001 |Malignant acantholytic squamous cell carcinoma (disorder)| |
1260076006 | Small cell non-keratinizing squamous cell carcinoma of lung (disorder) | OUTDATED | REPLACED BY | 1402256009 |Malignant nonkeratinizing squamous cell carcinoma of lung (disorder)| |
698048006 | Undifferentiated nonkeratinizing squamous cell carcinoma of nasopharynx (disorder) | OUTDATED | REPLACED BY | 707705008 |Malignant nonkeratinizing squamous cell carcinoma of nasopharynx (disorder)| |
402912009 | Vulval verrucous carcinoma of Buschke-Löwenstein (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409177000 |Malignant verrucous carcinoma of vulva (disorder)| |
402912009 | Vulval verrucous carcinoma of Buschke-Löwenstein (disorder) | AMBIGUOUS | POSSIBLY EQUIVALENT TO | 1409176009 |Giant condyloma acuminatum of vulva (disorder)| |
14442007 | Generalized keratoacanthoma (morphologic abnormality) | OUTDATED | REPLACED BY | 58220003 |Keratoacanthoma of uncertain behavior (morphologic abnormality)| |
448406002 | Grade III squamous intraepithelial neoplasia with microinvasive squamous cell carcinoma (morphologic abnormality) | ERRONEOUS | REPLACED BY | 12478003 |Malignant microinvasive squamous cell carcinoma (morphologic abnormality)| |
417049003 | Localized keratoacanthoma (morphologic abnormality) | OUTDATED | REPLACED BY | 58220003 |Keratoacanthoma of uncertain behavior (morphologic abnormality)| |
1187092008 | Malignant keratoacanthoma (morphologic abnormality) | OUTDATED | REPLACED BY | 58220003 |Keratoacanthoma of uncertain behavior (morphologic abnormality)| |
399739006 | Metaplastic squamous cell carcinoma (morphologic abnormality) | OUTDATED | REPLACED BY | 1162767002 |Malignant squamous cell carcinoma (morphologic abnormality)| |
25910003 | Papillary carcinoma (morphologic abnormality) | DUPLICATE | SAME AS | 39056008 |Malignant papillary squamous cell carcinoma (morphologic abnormality)| |
128674003 | Papillary microcarcinoma (morphologic abnormality) | OUTDATED | REPLACED BY | 1336196002 |Malignant papillary thyroid carcinoma (morphologic abnormality)| |
733897002 | Pseudovascular squamous cell carcinoma (morphologic abnormality) | OUTDATED | REPLACED BY | 85956000 |Malignant acantholytic squamous cell carcinoma (morphologic abnormality)| |
399494004 | Squamous cell carcinoma in post-traumatic skin lesion (morphologic abnormality) | NONCONFORMANCE_TO_EDITORIAL_POLICY | REPLACED BY | 1162767002 |Malignant squamous cell carcinoma (morphologic abnormality)| |
128633003 | Squamous cell carcinoma with horn formation (morphologic abnormality) | OUTDATED | REPLACED BY | 1162767002 |Malignant squamous cell carcinoma (morphologic abnormality)| |
45490001 | Squamous cell carcinoma, large cell, nonkeratinizing (morphologic abnormality) | OUTDATED | REPLACED BY | 1366051002 |Malignant nonkeratinizing squamous cell carcinoma (morphologic abnormality)| |
399582005 | Squamous cell carcinoma, nonkeratinizing, differentiated (morphologic abnormality) | OUTDATED | REPLACED BY | 1366051002 |Malignant nonkeratinizing squamous cell carcinoma (morphologic abnormality)| |
399694008 | Squamous cell carcinoma, nonkeratinizing, mixed differentiated and undifferentiated (morphologic abnormality) | OUTDATED | REPLACED BY | 1366051002 |Malignant nonkeratinizing squamous cell carcinoma (morphologic abnormality)| |
35718007 | Squamous cell carcinoma, small cell, nonkeratinizing (morphologic abnormality) | OUTDATED | REPLACED BY | 1366051002 |Malignant nonkeratinizing squamous cell carcinoma (morphologic abnormality)| |
449778005 | Undifferentiated nonkeratinizing squamous cell carcinoma (morphologic abnormality) | OUTDATED | REPLACED BY | 1366051002 |Malignant nonkeratinizing squamous cell carcinoma (morphologic abnormality)| |